Seminar 4: May 12th

On May 12th, from 16:00 – 17:15, our keynote speaker will be Prof. Dr. Gerald Shulman of Yale University in the USA. He will be joined by Dr. Kasper ter Horst of the Amsterdam UMC.

Prof. Dr. Gerald Shulman (Yale University)

“The evolutionary basis of insulin resistance: Implications for cardiometabolic disease, NAFLD/NASH and cancer”

The following review can be used as background material for the seminar:

Dr. Shulman is the George R. Cowgill Professor of Medicine and Cellular & Molecular Physiology at Yale. He is also Co-Director of the Yale Diabetes Research Center and was an Investigator of the Howard Hughes Medical Institute for 21 years. Dr. Shulman has pioneered the use of magnetic resonance spectroscopy combined with mass spectrometry to non-invasively examine intracellular glucose and fat metabolism in humans and transgenic rodent models that have led to several paradigm shifts in our understanding of type 2 diabetes (T2D), including the molecular mechanisms by which lipids promotes liver and muscle insulin resistance, as well as developing new drugs for the treatment of T2D, nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Dr. Shulman is the recipient of the Stanley J. Korsymeyer Award from the American Society for Clinical Investigation, the Outstanding Clinical Investigator Award from the Endocrine Society, the Solomon Berson Award from the American Physiological Society and the Banting Medal for Lifetime Scientific Achievement from the American Diabetes Association. Dr. Shulman is a Fellow of the American Association for the Advancement of Science, Inaugural Fellow of the American Physiological Society, Mastership in the American College of Physicians, Mastership in the American College of Endocrinologists and he has been elected to the American Society for Clinical Investigation, the Association of American Physicians, the National Academy of Medicine, the American Academy of Arts and Sciences and the National Academy of Sciences.

Dr. Kasper ter Horst (Amsterdam UMC)

“Demystifying the hepatic insulin resistance paradox in humans”

I am an internal medicine resident and working towards my career ambition of combining patient care with metabolic research. In 2017, I obtained a PhD on the clinical, nutritional, and molecular aspects of insulin resistance in humans. My current interests include the role of the brain in overeating, obesity, and insulin resistance; the mechanisms by which increased fructose consumption contribute to metabolic complications; and the mechanisms underlying ectopic lipid accumulation.