Program

Day 1 10 March, 2020
9.30 – 10.30Registration and coffee
10.30 – 10.45Opening remarks
Session 1: Drug intervention studies promoting energy metabolism
10.45 – 11.05Selected speaker: Dicky Struik (UMCG) – The translational
potential of fibroblast growth factor 1 in the treatment of
chronic metabolic diseases
11.05 – 11.25Selected speaker: Ellen de Heer (UMCG) – Downregulation of
glycogen synthase 1 (GYS1) decreases breast cancer cell
proliferation and enhances sensitivity to mitochondrial inhibition
11.25 – 11.45Selected speaker: Esther Zaal (UU) – Rewiring of energy
metabolism drives resistance to the proteasome
inhibitor bortezomib
11.45 – 12.30Keynote: Prof. Dr. Stephan Herzig (Helmholtz Diabetes Center) – Tissue communication in metabolic control
12.30 – 13.30Lunch 
Session 2: Intracellular and molecular metabolism
13.30 – 13.50 Selected speaker: Stijn Meijnikman (AUMC) –
Hyperinsulinemia, a key player in visceral adipose tissue and
hepatic cellular senescence
13.50 – 14.10 Selected speaker: Jeffrey Kroon (AUMC) –
Atherogenic lipoprotein(a) increases vascular glycolysis,
thereby facilitating inflammation and leukocyte extravasation
14.10 – 14.30 Selected speaker: Edgar Nollet (AUMC) –
Mitochondrial dysfunction is common in clinical and experimental settings of hypertrophic cardiomyopathy
14.30 – 15.15Keynote: Prof. Dr. Johan Auwerx
(École Polytechnique Fédérale de Lausanne) –
Systems genetics approaches to explore mitochondria and aging
15.15 – 16.00Coffee break
16.00 – 17.00Honorary lecture: Prof. Dr. Ronald Wanders
(Amsterdam UMC)
Human metabolism requires the crosstalk between different subcellular organelles: Lessons learned from genetic metabolic diseases
17.00 – 17.45Poster pitch presentations:
Jeroen Baardman (AUMC)
Anne Gemmink (MUMC)
Andrea Kodde (Danone)
Jiayi Pei (UMCU)
Katrin Rabold (RUMC)
Martijn Rutten (UMCG)
Milena Schönke (LUMC)
Pomme Simons (MUMC)
Katy van Galen (AUMC)
Taolin Yuan (WUR)
17.45 – 21.00Poster session with dinner and drinks
21.00 –  Evening program
Day 211 March, 2020
7.30 –
8.15
Boot camp
8.30 – 9.30Breakfast
Session 3: Systemic metabolism and inter-organ communication
9.30 – 9.50 Selected speaker: Xinwei Chang (MUMC) – The effect of chyme reinfusion on the bile salt/fibroblast growth factor 19 signaling
axis in intestinal failure patients with a temporary jejunal double enterostomy
9.50 – 10.10 Selected speaker: Joanne Hoogerland (Institut Pasteur de Lille/UMCG)  – Hypoglycemia aggravates dyslipidemia in GSD
Ia via enhanced adipocyte lipolysis and impaired VLDL catabolism
10.15 – 11.00Keynote: Prof. Dr. Antonio Moschetta
(Università degli Studi di Bari Aldo Moro)
The GUT liver axis: focus on FXR and FGF19
11.00 – 11.30  Coffee tasting
Session 4: Lifestyle interventions and circadian biology
11.30 – 11.50 Selected speaker: Jeroen van der Velde (LUMC) –
Liver fat, visceral fat and total body fat as mediators in the associations of physical activity and sedentary time with insulin resistance
11.50 – 12.10 Selected speaker: Jan‐Frieder Harmsen (MUMC) –
Human skeletal muscle exhibits a day‐night rhythm in lipid droplets and in the muscle lipidome
12.15 – 13.00Keynote: Dr. Pam Taub
(University of California San Diego) – Impact of time restricted
eating on cardiometabolic disease
13.00 – 14.00Lunch
Session 5: Innovative methods for metabolic research
14.00 – 14.20 Selected speaker: Andrea Cabbia (TU/e) –
Characterization of individual responses to endurance training
in older adults’ skeletal muscle metabolism using genome‐scale metabolic models
14.20 – 14.50 Selected speaker: Tineke van de Weijer (MUMC) –
PCr/ATP ratio’s measured with 31P‐MRS do not
reflect atrial cardiac mitochondrial function
14.55 – 15.30Keynote: Prof. Dr. Marc Hellerstein
(University of California Berkeley) – Measuring molecular flux
rates in humans through pathways that drive disease: Recent advances and applications in clinical medicine and drug development
15.30 – 16.00Final remarks, Conference evaluation, and Prizes